Which route of medication administration involves applying medications through the skin?

The topical route of medication administration is specifically designed for applying medications directly to the skin or mucous membranes. This method allows for localized treatment by delivering the medication where it is needed, such as for skin conditions like rashes or infections. Additionally, some medications can be formulated for systemic absorption through the skin, such as patches that release medication over time.

In contrast, other routes like the oral route involve swallowing medication, which must be absorbed through the gastrointestinal tract. The intravenous route delivers medications directly into the bloodstream through a vein, allowing for immediate effects. The subcutaneous route involves injecting medications into the tissue layer between the skin and the muscle, primarily for systemic effects rather than local application. Therefore, the topical route is distinct in that it focuses on direct application to the skin, making it the correct choice.